Saturday, June 30, 2012

Taming the Psychopath Within


Neuroscientist James Fallon shared the stage with clinical psychologist Kay Redfield Jamison and lawyer Elyn Saks, who specializes in law and psychiatry, at the World Science Festival program, Madness Redefined: Creativity, Intelligence and the Dark Side of the Mind, held at the Kaye Playhouse at Hunter College in New York City this June. Here, Fallon shares a bracingly honest account of his life with bi-polar disorder, OCD and panic attacks.

I?m a serotonin train wreck, and I love it. I don?t feel as if I suffer from a mental disorder, but am rather blessed by it. While this may appear to be a bit of denial, a bit of eccentric goofiness, which all may be true too, the crazy quilt of genetic gifts I received from my parents, and more the enlightened way they and my family treated me, provided a powerful fulcrum to succeed, and fully enjoy it all, in spite of sloshing in some funky dark groundwater along the way.

Most of the conditions and symptoms I displayed are familiar to any family. At two I began a lifetime of chronic asthma, full blown obsessive compulsive disorder starting around puberty, years of scrupulous hyper-religiosity and hints of endogenous depression. Then in my late teens two decades of recurrent panic attacks, about 850 in all, each promising certain death riding on a galloping heart beat and blood pressure spikes of 230/140+. This paralleled a lifetime of the ever popular smoking and alcohol abuse, obesity swings of 100 pounds and more twice a decade, 4 hour nights of sleep with apnea and heroic snoring, chronic hypomania embedded within a mild bipolar disorder, and the late life surprise, discovering a latent psychopath inside, not fully, but too close for friends and loved ones.

By ordinary measure, this lifetime of unrelenting psychiatric problems would seem horrifying. But not to me. My life always, from my first memory, seemed charmed and wonderful. The early conditions were always associated with a sense of imminent doom, as untreated asthma, OCD, and panic attacks would to a kid, but these were also associated with insights into myself, and a hint of what suffering people with real problems had. The allergic asthma and anaphylactic shock during my medical exam kept me out of Vietnam and may have saved my life. I was told later in life by my parents that when I was very young I told them I wanted to be a doctor because I knew what it must be for people to suffer. The chronic sleep deprivation was associated with fantastic visions, vivid dream sequences I wouldn?t give up for the world, they feel that exhilarating. In these states ideas would flood over me, and these ideas were both weird and true, and trained me to think out of the proverbial box, which definitely helped my scientific career, where I learned to receive, accept, and try out ideas that emerged from anywhere in my head, and at the most unexpected times and unusual circumstances.

In these states ideas would flood over me, and these ideas were both weird and true, and trained me to think out of the proverbial box, which definitely helped my scientific career, where I learned to receive, accept, and try out ideas that emerged from anywhere in my head, and at the most unexpected times and unusual circumstances.

The OCD would last only about six years, but that trained me to focus and be hyper vigilant, which also help train me to stay on tasks throughout life, and finish them with a fury. They also helped me develop a will to win, to a fault perhaps, but to also stop my heavy smoking and drinking and the will to lose 100 pounds when the spirit moved me. Keep the weight off? That?s another matter. The bipolar disorder did have its many moments of complete dread and darkness, the overwhelming fear of not existing, but 99 percent of the time the bipolar was all about hypomania, a most wonderful upbeat ?affliction? no hypomanic wants to treat.

Associated with all of these swings of mood and behavior came bursts of creativity and productivity in science and in the arts. A peculiarity of bipolar disorder, and to less an extent, fronto-temporal dementia, schizophrenia and psychopathy, is that a dysfunctional frontal lobe and imbalanced temporal lobe can release hidden creativity. What a gift!

Those positive feelings and traits and triumphs far exceed the negatives to me, and for that I am eternally grateful to the gods of serotonin, dopamine, and norepinephrine. But what about the most disturbing revelation of all that happened in my 60s, supposedly the decade of peak cognitive performance? To me the psychopathic traits are a curiosity, to people close to me, a sometimes curse. But they too feel that in general, the positive parts of me as a friend and family member, edge out the negatives, by a nose perhaps, but hey, life is a horse race, no? We take the thoroughbred we were born with, and ride it to victory, warts and all.

This article originally appeared at the World Science Festival blog.

Source: http://rss.sciam.com/click.phdo?i=d3fe36fbe6061820a528660efb8a5cdf

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Customer Service After the Sale Still Devices Business Income - Part 1

The phone call center customer service director job information includes foremost a staff of 10-20 associates depending on the energy of the firm and directing them to reach the monthly workforce targets. The lender customer service manager job description includes dealing with your customers and resolving their requests regarding the performing of the balances and other products and services offered by the bank.

Tell them regarding the STAR formatting and that you are trying to find examples of certain competencies, hand them over a few examples of the competencies you are searching for.

Helpdesk services are offered round the clock at an affordable price tag if you delegate them. Even so, take the time to be aware of the terms and conditions in the contract when you hire the business enterprise process entrusting service provider.

Almost all customer service reps are merely doing the job so as to advance in the company as well as gain the information and associates they need to manage their goals. My own mail to sit at a desk putting on that head set for the rest of the lives. Frequently it?s hard to motivate those individuals and that?s something that team leaders need to address. In the event the employees are failing to take their careers seriously and are not enthusiastic, it can lead to important trouble.

Create a customer service mission. This begins with discovering the significant effects that your business? services dress in both ones internal along with your external customers. Glimpse beyond the noticeable features of your service or service to search for the benefits they offer to your customers. One example is, a company that produces anti-lock brakes does more than manufacture a product. The product may ultimately save lives.

The success of any organization lies on how core staff manage initiatives and handle staff members. If you want to gain a sure company success from the individual level up, taking note of this on managing training types-and employing them-should be your final task.

Nearly all disabled shoppers will take their own business to an organisation that?s built some sort of reputation for providing accessible and disability-friendly customer service so organizations must be able to offer this kind of ahead of the Game titles.

The company makes use of its Facebook or myspace profile to engage with customers, nevertheless, also employs the Ceramics Barn YouTube sales channel to build the community online. They have videos which include how-to?s for bash planners, custom profiles along with featured products. By giving tips to shoppers and providing them with a story at night products Art Barn gives buyers much more than a product and therefore builds up a great relationship together ? a hands-on form of customer service.

The problem is, you can?t fix what is not necessarily broken. To be able their clients acquired decided not to grumble, they were nothing the wiser as to their customers disapproving or being unhappy with their service.

Service Recuperation ? Marriott Hotels makes use of the service retrieval acronym Discover: Listen, Sympathise, Apologize, Answer, Notify (ones supervisor as well as co-workers so that it doesn?t happen again in order to future customers). Other businesses utilize the acronym LAST: Listen. You are. Solve. Give thanks to (the customer for bringing the matter to your interest). What are the service recuperation steps you expect each and every employee to adopt when confronted with any dissatisfied customer?

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Posted by PettigrewSusy on June 30, 2012. Filed under Miscellaneous. You can follow any responses to this entry through the RSS 2.0. Both comments and pings are currently closed.

Source: http://www.technoreporter.com/miscellaneous/customer-service-after-the-sale-still-devices-business-income-part-1/

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Twitter's Mobile Ads Begin to Click

Twitter Inc. is showing early signs of success selling advertising on mobile devices, an area that is bedeviling Internet companies including Facebook Inc. and Google Inc.

On most days, Twitter is now generating the majority of its revenue from ads shown to its users on mobile gadgets, rather than from ads on Twitter.com, company executives said. One key reason: People who see a Twitter ad on their phones are more likely to click or interact with it in some way, which is how Twitter gets paid for advertisements.

The San Francisco company has only been offering mobile ads in earnest since April, and some companies buying Twitter ads said they haven't kept tabs on the effectiveness of their campaigns on mobile devices.

But P.F. Chang's China Bistro Inc. is among the advertisers that say they were surprised at how many people are clicking on Twitter mobile ads.

The Scottsdale, Ariz.-based restaurant chain this winter spent $25,000 to pitch a Lunar New Year promotion to people on Twitter. P.F. Chang's arranged to push posts promoting dining rewards to Twitter users, including those searching for terms such as "Chinese New Year," on their mobile phones or their personal computers.

In the first four days of the campaign, P.F. Chang's said roughly 1 million people clicked, recirculated or otherwise interacted with the Twitter ad. Of those people, roughly 70% did so from mobile devices rather than computers.

As P.F. Chang's began seeing the results, the company quickly shifted that entire Twitter ad budget to mobile, said Jason Miller, digital content and community manager for P.F. Chang's.

"The results were staggering," Mr. Miller said. He added that P.F. Chang's in April kicked off another $25,000 Twitter ad campaign to pitch lunch offerings. Mr. Miller said it hasn't been as effective in generating clicks or in pushing up restaurant sales.

He speculated that Twitter ads may be better for time-sensitive events rather than for awareness-building efforts. "That may be where Twitter ads fall flat," Mr. Miller said.

Twitter says its mobile-advertising business is working because a company can easily convert any tweet into an ad.

The format of ads on Twitter's mobile and desktop sites are the same, and advertisers pay the same rate no matter the platform. On many mobile services including Google's, ad rates are lower in part because advertiser demand is lower.

Twitter also says its users are more active on mobile devices, which may explain why interaction with ads is higher, too. About 60% of its 140 million monthly users access the service on mobile devices.

"We know that mobile is how people access Twitter, it's where people are overall, and we know it's where the business is," said Adam Bain, Twitter's president of global revenue.

Twitter, which is closely held, declined to specify its ad revenue. But eMarketer Inc. expects Twitter to produce $259.9 million from advertising this year, up from an estimated $139.5 million in 2011. The research firm and other analysts don't break out Twitter's revenue forecasts from mobile devices.

Investor expectations are high that Twitter, which has a private-market valuation of roughly $8.4 billion, can amp up its advertising sales ahead of an initial public offering that people close to the company expect in a year or more.

Overall, the potential growth in mobile advertising is enormous, but elusive for many companies. U.S. advertising on cellphones and tablets reached $1.6 billion in 2011?only about 5% of all ad spending, according to the Interactive Advertising Bureau.

Some research shows consumers are more likely to notice ads on their phones, in part because they still are novel. But smaller screen sizes than PCs, less sophisticated ad targeting and wariness by advertisers is holding down ad rates or spending on mobile devices.

Executives at Google have said they are devoting resources to close gaps in the ad rates they make from mobile devices compared with PCs. The lower cost of Google's mobile ads compared with those viewed on a desktop have contributed to an overall downturn in the average amount paid by advertisers every time someone clicks on an ad, the company has said.

Google recently made it simpler for more than one million of its advertisers to buy ads across platforms.

In October, the company said it was on pace to generate $2.5 billion annually in mobile-ad revenue, its last public figure on the topic. The company made about $36.5 billion in revenue from advertising last year.

Facebook, which made $3.15 billion last year from advertising, has only begun experimenting with mobile ads, selling what it calls "sponsored stories," in which marketers pay Facebook to republish positive messages that users post about their brand.

The mobile-ad push is crucial given that more than half of the social network's 900 million users access the site on mobile devices.

"We've seen powerful indicators that when people see sponsored stories on mobile they engage," said Carolyn Everson, Facebook vice president of global marketing solutions.

Doubts remain that Twitter's ad business?which is about two years old?will ever be as big as Facebook's or Google's.

Twitter "still has a lot of growth to accomplish before they can make advertising a big business," eMarketer analyst Debra Aho Williamson said.

Still, CloudOn Inc. is a Twitter believer. The Palo Alto, Calif., business-software company said its Twitter ads helped generate close to 10,000 downloads of its free document-software app for Apple Inc.'s iPad.

Jay Zaveri, CloudOn's vice president of product and marketing, said when the start-up targeted Twitter ads in the past few months to mobile devices, about 2.5 of every 100 ads resulted in an app download?about three times the download rate of ads on Twitter.com, and better than other advertising services CloudOn has used.

"It's been a very good experience," he said.

Write to Shira Ovide at shira.ovide@wsj.com

Source: http://europe.wsj.com/article/SB10001424052702304458604577491170573156612.html?mod=rss_asia_whats_news

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Friday, June 29, 2012

hobbledehoy_rec: @musicforheroes how does canada treat refugees?

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Governments of Canada and the United States to Strengthen Co-operation on Forest Health Issues

OTTAWA, ONTARIO--(Marketwire - June 28, 2012) - Forest sector officials from Canada and the U.S. gathered over the past two days in Washington, at the first-ever summit on forest health, to advance scientific co-operation on shared challenges. Officials identified research areas in which collaboration and knowledge exchange could enable both countries to better protect the health and sustainability of the two nations' forests.

"This summit is an important first step toward the creation of a Canada-U.S. forest science agenda," said the Honourable Joe Oliver, Minister of Natural Resources Canada. "By identifying issues we can work on together, we aim to maximize the value of the critical work that scientists and researchers are doing on both sides of the border to ensure the health of our forests and forest sector."

Canada and the U.S. have a long and successful history of collaborating on resource-related issues. "The borders that separate the United States and Canada don't segregate threats to our natural resources," said U.S. Agriculture Secretary Tom Vilsack. "The countries share common environmental concerns. It is critical that we continue to collaborate and address current and future land management challenges as partners."

The mountain pine beetle is one such challenge. The beetle is a native insect that has seriously impacted forest stands across the western half of North America, resulting in the direct loss of tens of billions of dollars in environmental services and economic benefits.

Participants at the forest health summit agreed that the nature and scope of the issues faced today across the continent may go beyond the individual capacity of any single organization. Greater knowledge exchange and a complementary research agenda would help rally science and policy expertise within organizations from both countries.

NRCan's news releases and backgrounders are available at www.nrcan.gc.ca/media.

Source: http://www.marketwire.com/mw/release.do?id=1675225&sourceType=3

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DNPTR: At No 32 (2nd round) the Cavs draft 6-10 center Bernard James from Florida State

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Source: http://twitter.com/DNPTR/statuses/218535655070904321

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Thursday, June 28, 2012

Oil hovers above $79 after US crude supply jump

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PressHerald: Maine Heritage Policy Center director confirms he's joining GOP Charlie Summers' U.S. Senate campaign. http://t.co/kyO6nxJg #mepolitics

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Wednesday, June 27, 2012

'Done...for you big boy;' How emails nailed Barclays

By Steve Slater and Kirstin Ridley , Reuters

LONDON -- "Done ... for you big boy," read a message sent by a Barclays banker to one of the lender's traders, who had asked him to fix a key lending rate artificially low.

"Dude, I owe you big time! Come over one day after work and I'm opening a bottle of Bollinger," a trader from another firm emailed a banker at Barclays, showing his thanks for the rate set artificially low.

UK-based Barclays has agreed to pay $453 million in fines to UK and U.S. regulators to settle its part of an investigation into whether banks manipulated the London Interbank Lending Rate, know as Libor.

Investigators were helped by extensive emails and other messages about Libor, a set of benchmarks designed to indicate the rate at which banks estimate they are able to lend to each other. Libor is used to set corporate and personal borrowing rates worldwide.

Communications released by authorities on Wednesday showed Barclays traders calling each other "superstar" and with little concern for covering their tracks as they urged colleagues responsible for submitting Barclays' Libor rates to try and influence final prices.

Requests came in such as: "We need a really low 3m fix, it could potentially cost a fortune. Would really appreciate any help."

And: "Your annoying colleague again ... Would love to get a high one month. Also if poss a low three month ... if poss ... thanks."

Traders made their requests in person, via email and through electronic "chats" over an instant messaging system.

On a few occasions, some traders even made entries in electronic calendars to remind themselves what requests to make of Barclays' Libor submitters the next day.

One trader would shout across the desk to make sure other traders had no conflicting preference to ask the Libor submitters.

"The traders were barking orders like they were at a fast food drive-through and the submitters were so accommodating that they might as well have said, 'do you want fries with that'," said Bart Chilton, a commissioner at the U.S. Commodity Futures Trading Commission, which led the settlement agreement.

Some 257 requests were made to rate submitters from at least 14 Barclays derivatives traders over four years. Traders at other banks also tried to influence Barclays' rate, while Barclays' traders put pressure on the rates offered by others.

Most of the world's biggest banks are under investigation as regulators from Europe, North America and Japan attempt to prove banks rigged rates. Barclays is the first to settle.

"This is the way you pull off deals like this chicken, don't talk about it too much, 2 months of preparation... the trick is you do not do this alone ... this is between you and me but really don't tell ANYBODY," a Barclays trader told a trader at another bank.

Investigators said Barclays derivatives traders got the bank to submit inaccurate rates between 2005 and 2008 so they could profit. The bank also submitted artificially low rates from September 2007 to May 2009 to ease fears it faced funding problems during the financial crisis.

Judging by the messages, Barclays was not alone in having an interest in lowering their submitted rates during the crisis to avoid signaling to markets their distress.

On one occasion, a manager said if Barclays submitted its correct rate, "It's going to cause a @!$%# storm," and the bank submitted a lower rate.

But the bank's treasury staff were beginning to become uneasy. In late 2007, Barclays told the UK Financial Services Authority and the British Bankers' Association, the trade body under whose auspices Libor is set, of its concerns that rivals were setting rates too low.

Months later, a senior Barclays treasury manager called the BBA and warned them that rates were not accurate, but that Barclays was not the worst offender.

"We're clean, but we're dirty clean, rather than clean-clean," he said.

"No-one's clean-clean," the BBA representative responded.?

Copyright 2011 Thomson Reuters. Click for restrictions.

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Google likely to unveil small tablet at show

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Google Nexus Q is 'Designed and Manufactured in the U.S.A.'

Google didn't touch on it during its keynote, but The New York Times' John Markoff has the story on one fairly unique feature of its new Nexus Q home media device: the base of the unit proudly boasts that it's "Designed and Manufactured in the U.S.A." That includes an unnamed company in the Midwest that manufactures the metal base and another in Southern California that makes the case, while the device itself was reportedly being assembled just last week at a large factory 15 minutes away from Google's HQ. According to Google, it hopes that people will be willing to pay more for the device as a result ($299, if you missed it), but it has no plans to play up the "Made in the U.S.A." angle in its marketing. Wired also has an in-depth piece of its own on the making of the device -- you can find it linked below as well.

Check out our full coverage of Google I/O 2012's opening keynote at our event hub!

Google Nexus Q is 'Designed and Manufactured in the U.S.A.' originally appeared on Engadget on Wed, 27 Jun 2012 13:58:00 EDT. Please see our terms for use of feeds.

Permalink   |  sourceThe New York Times  | Email this | Comments


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Tuesday, June 26, 2012

Say ?hell no? to this manipulative president, Part Two (Powerlineblog)

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Understand More About Diverse Techniques To Increase Your Fitness

Getting fit is more than your outward look. Increase the long life and the grade of your way of life by way of standard workout routines. Grow an attitude that facilitates a proper improvement in how you live. This gives you the proper ways to get great knowledge on your own fitness experience.

Chin-ups can be the bain of the living should you allow them to be, but there are ways to cause them to a little simpler. Modifying your way of thinking can even be of great assistance. Try to think that your elbows are yanking downward while you are performing a chin-up. You may chat yourself into thinking they are less difficult and therefore you can expect to do a lot more.

Should you be a smoker, you need to cease without delay to not only stop very early loss of life, but to enhance your overall health total. You can give up smoking no matter how lengthy you might have got the habit. You can expect to lower your probability of sliding target to many people dreaded ailments and boost your life expectancy at the same time. Display your body you cherish it by stop smoking.

Don?t be scared. Cycling is another superb exercise process. Bike to function as being a wholesome substitute for driving a vehicle. Should your 1-way drive is 5 various a long way or much less, it will consider you no longer than half an hour to drive for your work.

To be able to get a lean body, it commences if you make great judgements within the initial minutes or so of your morning hours. Your morning meal is important if you would like succeed at meeting your long term and quick-term workout goals. Your morning meal also strike-starts your fat burning capacity.

Are you searching for techniques for getting more effect out of your exercises? It is possible to build power by 20 % in the event you stretch. Take about a 30 seconds to stretch out your muscles among units. Your exercise routine could be more powerful by simply extending.

Try including some range to your physical fitness regimen. This will be significant for a lot of reasons. When you use a similar regimen every day, you increase the chance that you can become tired of your exercise routine. Also, as soon as your system receives utilized to your regular exercise program, it?ll be much easier to full, as well as the final results you get is going to be significantly less spectacular. Bring in new exercises as often as you can to help keep things entertaining and new.

Like with any exercising, ensuring your wandering kind is appropriate is a vital aspect in avoiding traumas. Keep the again directly, together with your shoulders back. Your forearms must remain curved at an perspective of about 90 levels. Ensure your hands are opposing your ahead ft .. In every single step, make certain that your hindfoot initially reaches the ground then roll your feet forwards.

Allocate a percentage of the waking up existence to routines which entail physical fitness. If you have exercise-stuffed days that do not enable any health and fitness, this may be a problem with your exercise. You can use downtime for health and fitness time.

To stay encouraged, most people must see outcomes each day as encouragement. Scales may not motivate you adequate. Put on some clothing you employed so that you can use. For motivation always keep fitting restricted-appropriate outfits and you will definitely notice the results and find out the advancement you happen to be creating.

A great way to strengthen your forearms is always to carry out the exercise routines that tennis games participants do. Placed a newspaper on any smooth area you might have useful. Just work at rumpling up the entire local newspaper for half a minute. Utilize your dominating palm. Soon after practicing this physical exercise 2 times, swap hands and wrists and perform the identical action as soon as, then twice much more along with your superior hand.

In order to increase the size of your quadriceps, perform pack squats. You will get much better results by undertaking box squats which will help you with regular leg squats. You simply need a pack to put powering you. You are likely to pause lightly as you are coming back downward from your squat.

Plunge bomb pushups are a fantastic difference of regular pushups. All you need to do is keep your hands and wrists and ft pressing the ground whilst arching your back. Bend each arm on the elbow joint parts, then drive your torso forwards and transfer your body downward. The very last motion into a dive bomb pushup would be to press your whole body straight back to the starting place. This does magic for your chest area muscle tissue.

The main topic of health and fitness involves a wide array of ideas, concepts and frequently, quite conflicting views. Despite the mixed viewpoints and ideas, there are several distinct stuff you need to and really should not be carrying out with your fitness routine. Adhere to the suggestions on this page to kick your exercise into substantial products.

Should you fancy supplementary points about uprightrows check out Felisha E. Nohe?s site there is loads of information not detailed in this post, find those details at Author?s web blog to discover more.

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Boat Capsizes In Irvine Lake, Two Men Dead (VIDEO)

Irvine Lake Boat Capsize

Two men are dead after a boating accident in Irvine Lake, Calif. (CBS)

ORANGE, Calif. -- The bodies of two fishermen have been recovered after their boat capsized in a Southern California lake overnight.

Orange County Sheriff's Lt. Jim England says divers found the men Sunday morning after several hours of searching in Irvine Lake in Orange.

A security guard was on a patrol shortly after midnight when he spotted a small fiberglass boat upside down in the water. The guard saw two heads in the water and went to rescue the two men.

Those men said two of their friends were still in the water, so divers were called in to look for the missing men.

The names of the dead have not been released.

Contribute to this Story:

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Monday, June 25, 2012

Volatile Spirits: Tasting Wine!!!

I still remember the first day I tasted wine ever. My cousin had taken our gang out, and red wine was ordered. I remember wincing at the first sip... but there was something in that sour taste blended with a quaint sweet flavour. I not only finished that glass, but although I am an essentially non alcoholic person, I would love to have a glass or two of wine occassionally. Oops, that's a secret let out!!!

So, when my blogger-and-more buddy, Sushmita?invited me for a Wine Tasting?event organised by ?Four Seasons, I readily agreed ignoring the fact that it was on a Thursday afternoon. The venue was near my office, Fresco Restaurant in Connaught Place, which is famous for exotic Italian food. I was joined by seven fellow bloggers, (left to right in the picture): Rituparna, Pratik, Purba, Deeba, Sushita, Sangeeta and Rekha.

The bright face you see behind our group is Shamita Singha, Miss Earth Universe. She came across as the girl next door and told us about wines, about Four Seasons and interacted with us freely. Never for once, did she sound like a celebrity. But she sure knew a lot about wines!

I mean, I have consumed wine on various occasions at different restaurants in a?number of cities, and used to think myself as?quite a? connoisseur. But never had I bothered to think how wine was made, where it got its colour from, etc. Shamita told us all this,and gave us ideas about pairing different types of?wine with the type of cuisine. Yes, dont be surprised if I serve you wine with Baingan-ka-bharta (Roasted brinjal, a delicacy from the Indian cuisine)?now!?We tasted five types of wines over enthralling converstation, and were quite tipsy and gay by the end of the session. Two smart representatives from Four Seasons, Jyoti and a handsome young man (sorry, I forgot to ask his name) kept us company enthusiastically over the food and drinks.

We were gifted a complimentary bottle of wine for our friends and family. So come over, if you want to share my newly gained knowledge and taste the wine.

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Sunday, June 24, 2012

Nik__Fury: @ASciorra hope you had a blast at the Coney Island Mermaid Parade!

Sorry, Readability was unable to parse this page for content.

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Neurons that control overeating also drive appetite for cocaine

Neurons that control overeating also drive appetite for cocaine [ Back to EurekAlert! ] Public release date: 24-Jun-2012
[ | E-mail | Share Share ]

Contact: Karen N. Peart
203-432-1326
Yale University

Researchers at Yale School of Medicine have zeroed in on a set of neurons in the part of the brain that controls hunger, and found that these neurons are not only associated with overeating, but also linked to non-food associated behaviors, like novelty-seeking and drug addiction.

Published in the June 24 online issue of Nature Neuroscience, the study was led by Marcelo O. Dietrich, postdoctoral associate, and Tamas L. Horvath, the Jean and David W. Wallace Professor of Biomedical Research and chair of comparative medicine at Yale School of Medicine.

In attempts to develop treatments for metabolic disorders such as obesity and diabetes, researchers have paid increasing attention to the brain's reward circuits located in the midbrain, with the notion that in these patients, food may become a type of "drug of abuse" similar to cocaine. Dietrich notes, however, that this study flips the common wisdom on its head.

"Using genetic approaches, we found that increased appetite for food can actually be associated with decreased interest in novelty as well as in cocaine, and on the other hand, less interest in food can predict increased interest in cocaine," said Dietrich.

Horvath and his team studied two sets of transgenic mice. In one set, they knocked out a signaling molecule that controls hunger-promoting neurons in the hypothalamus. In the other set, they interfered with the same neurons by eliminating them selectively during development using diphtheria toxin. The mice were given various non-invasive tests that measured how they respond to novelty, and anxiety, and how they react to cocaine.

"We found that animals that have less interest in food are more interested in novelty-seeking behaviors and drugs like cocaine," said Horvath. "This suggests that there may be individuals with increased drive of the reward circuitry, but who are still lean. This is a complex trait that arises from the activity of the basic feeding circuits during development, which then impacts the adult response to drugs and novelty in the environment."

Horvath and his team argue that the hypothalamus, which controls vital functions such as body temperature, hunger, thirst fatigue and sleep, is key to the development of higher brain functions. "These hunger-promoting neurons are critically important during development to establish the set point of higher brain functions, and their impaired function may be the underlying cause for altered motivated and cognitive behaviors," he said.

"There is this contemporary view that obesity is associated with the increased drive of the reward circuitry," Horvath added. "But here, we provide a contrasting view: that the reward aspect can be very high, but subjects can still be very lean. At the same time, it indicates that a set of people who have no interest in food, might be more prone to drug addiction."

###

Other authors on the study included Jeremy Bober, Jozelia G. Ferreira, Luis A. Tellez, Yann Mineur, Diogo o. Souza, Xiao-Bing Gao, Marina Picciotto, Ivan Araujo, and Zhong-Wu Liu.

The study was supported by The National Institutes of Health Director's Pioneer Award to Horvath; and in part by the National Institute on Deafness and Other Communication Disorders.

Citation: Nature Neuroscience June 24, 2012, doi: 10.1038/nn.3147


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Neurons that control overeating also drive appetite for cocaine [ Back to EurekAlert! ] Public release date: 24-Jun-2012
[ | E-mail | Share Share ]

Contact: Karen N. Peart
203-432-1326
Yale University

Researchers at Yale School of Medicine have zeroed in on a set of neurons in the part of the brain that controls hunger, and found that these neurons are not only associated with overeating, but also linked to non-food associated behaviors, like novelty-seeking and drug addiction.

Published in the June 24 online issue of Nature Neuroscience, the study was led by Marcelo O. Dietrich, postdoctoral associate, and Tamas L. Horvath, the Jean and David W. Wallace Professor of Biomedical Research and chair of comparative medicine at Yale School of Medicine.

In attempts to develop treatments for metabolic disorders such as obesity and diabetes, researchers have paid increasing attention to the brain's reward circuits located in the midbrain, with the notion that in these patients, food may become a type of "drug of abuse" similar to cocaine. Dietrich notes, however, that this study flips the common wisdom on its head.

"Using genetic approaches, we found that increased appetite for food can actually be associated with decreased interest in novelty as well as in cocaine, and on the other hand, less interest in food can predict increased interest in cocaine," said Dietrich.

Horvath and his team studied two sets of transgenic mice. In one set, they knocked out a signaling molecule that controls hunger-promoting neurons in the hypothalamus. In the other set, they interfered with the same neurons by eliminating them selectively during development using diphtheria toxin. The mice were given various non-invasive tests that measured how they respond to novelty, and anxiety, and how they react to cocaine.

"We found that animals that have less interest in food are more interested in novelty-seeking behaviors and drugs like cocaine," said Horvath. "This suggests that there may be individuals with increased drive of the reward circuitry, but who are still lean. This is a complex trait that arises from the activity of the basic feeding circuits during development, which then impacts the adult response to drugs and novelty in the environment."

Horvath and his team argue that the hypothalamus, which controls vital functions such as body temperature, hunger, thirst fatigue and sleep, is key to the development of higher brain functions. "These hunger-promoting neurons are critically important during development to establish the set point of higher brain functions, and their impaired function may be the underlying cause for altered motivated and cognitive behaviors," he said.

"There is this contemporary view that obesity is associated with the increased drive of the reward circuitry," Horvath added. "But here, we provide a contrasting view: that the reward aspect can be very high, but subjects can still be very lean. At the same time, it indicates that a set of people who have no interest in food, might be more prone to drug addiction."

###

Other authors on the study included Jeremy Bober, Jozelia G. Ferreira, Luis A. Tellez, Yann Mineur, Diogo o. Souza, Xiao-Bing Gao, Marina Picciotto, Ivan Araujo, and Zhong-Wu Liu.

The study was supported by The National Institutes of Health Director's Pioneer Award to Horvath; and in part by the National Institute on Deafness and Other Communication Disorders.

Citation: Nature Neuroscience June 24, 2012, doi: 10.1038/nn.3147


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Saturday, June 23, 2012

Nest Learning Thermostat reportedly taken off Apple Store shelves

By AppleInsider Staff

Published: 01:30 AM EST (10:30 PM PST) The first product to come out of ex-Apple executive Tony Fadell's startup Nest, the Nest Learning Thermostat, has reportedly been quietly pulled from shelves at a number of brick-and-mortar Apple Stores for unknown reasons.

While it cannot be officially confirmed that Apple Stores have stopped selling the Nest thermostat altogether, AppleInsider contacted a random sampling of outlets and found that each had taken down its in-store display units.

Some employees, who wished to remain anonymous, said that they had been told to pull the item while others simply stated that they were out of stock. One location confirmed that the device was on site but had been locked away in a storage room for reasons unknown. The same store said it received no instructions beyond those to take the Nest off the sales floor.

At the time of this report the unit was still in stock and ready to ship on Apple's online store but curiously it was not available for in-store pickup. An Apple Store employee corroborated this information though had no further insight into the matter.

It is unclear why the thermostat was removed from the Apple Store, but a representative at a nearby location of Nest sales partner Lowe's said the big-box home improvement store received a new shipment on Thursday and plans to stock them on shelves within four to five days.

The brainchild of Tony Fadell, also known as the "grandfather of the iPod," the $250 Nest Learning Thermostat uses sensors and an on-board CPU to efficiently control temperatures according to a variety of environmental factors. Users can also control the unit with the iPhone 4S, iPhone 4, iPhone 3GS, all iPad models, and the third- and fourth-generation iPod touch.

The Nest is currently being sold under the "iPod accessories" category on Apple's online store and is listed as an "app-enabled accessory."

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Jeb Bush: Party elder statesman or 2016 candidate? (reuters)

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